Competition favourites Manchester United host Serie A side Roma in the first leg of their Europa League semi-final on Thursday, with the tie set to play a large role in defining both clubs' seasons. Coming into their fifth semi-final since the start of last year, United have yet to progress to a final during that time, while the under-performing Italian outfit arrive at Old Trafford on a run of just one victory from their last seven league games. In the semi-finals for the second successive year, Manchester United have been imperious in Europa League action since dropping down from the Champions League, as they previously dismissed Spanish sides Real Sociedad and Granada 4-0 on aggregate and saw off Roma's Serie A counterparts AC Milan in between. Though they have already lost four semis during boss Ole Gunnar Solskjaer's relatively brief reign - including last season's one-off tie with Sevilla - the Red Devils are now favourites to lift their first trophy since 2017's final success under Jose Mourinho. Manchester United possible starting lineup: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Pogba, Fernandes, Rashford; Cavani Roma possible starting lineup: Lopez; Cristante, Smalling, Ibanez; Karsdorp, Diawara, Veretout, Spinazzola; Pellegrini, Mkhitaryan; Dzeko