Weight loss tips: 4 reasons you can't lose weight. Losing weight is big business on a global scale. It’s estimated that weight loss programs and products generate more than $150 billion in annual profits in the US and Europe alone. Programs that require you to purchase special food, supplements and other products tend to be the costliest. Though “fat burners” and other diet pills are popular, they often aren’t regulated and may be downright dangeruos. Unfortunately, even those who aren’t very overweight appear willing to risk the potentially harmful consequences of taking diet pills. A study including more than 16,000 adults found that about one-third of those who took weight loss pills weren’t obese before they started taking the pills. Clearly, many people spend a great deal of effort and money trying to lose weight. And even if you don’t join a weight loss program or buy diet pills or products, you may end up devoting much of your free time and energy to the pursuit of being thin. Why Many Women Can’t Reach Their Goal Weight Many women spend a significant amount of money, time and effort on trying to lose weight. Nevertheless, some seem to make little progress. Several factors influence your ability to lose weight. 1. Health Conditions Certain diseases or disorders can make weight loss extremely difficult, including: Lipedema: Believed to affect nearly one in nine women worldwide, this condition causes a woman’s hips and legs to accumulate excess fat that is extremely difficult to lose. It often also causes easy bruising and pain. Hypothyroidism: Low levels of thyroid hormone lead to a slowdown in metabolism that can impede weight loss efforts. Polycystic ovary syndrome (PCOS): Keep reading!